2026 Q1
SunRay101 antibody screening expected to be completed in Q1 2026.
Metabolic Disease Therapeutics:
Metabolic Disease Therapeutics:
Exploring Precision Therapeutic Approaches for Metabolic Homeostasis
Precision Medicines Reshaping Metabolic Homeostasis
- Over 650 million people worldwide are living with obesity, yet no single drug can simultaneously achieve fat loss, muscle preservation, and correction of multiple metabolic disorders.
- Approximately 40% of weight loss from current anti-obesity drugs comes from muscle mass, leading to reduced metabolism and high rebound risk; no approved therapy currently exists for sarcopenia.
SUNRAY Approach
Leveraging the SoIndeep™ and SoInAb™ platforms, innovative biologics targeting the ActRII and GIPR pathways are being developed. The ActRII subtype-selective monoclonal antibody (SunRay101) is being investigated for its potential in modulating muscle wasting signaling, while preserving metabolic homeostasis-related pathways. The ActRII/GIPR bispecific antibody (SunRay102) is being explored for its potential synergistic effects on fat reduction, muscle gain, and glucolipid metabolism.
Proposed Indications
Obesity, Sarcopenia, Type 2 Diabetes, Heart Failure with Muscle Wasting, and beyond.
Potential Research Value
Offers patients with metabolic syndrome a single therapeutic solution addressing multiple pathologies, with particular strength in filling the current gap in muscle preservation.
Technology Infrastructure
R&D across all four application domains is supported by the following three technology platforms:
Metabolic Disease Therapeutics
Musculoskeletal Regeneration
Regenerative Biomaterials
Smart Health Management
AI De Novo Antibody Platform
Directly generates antibodies against antigen epitopes, reducing R&D costs by 70%
AI Cell Screening Platform
Tens of millions of data points accumulated; participates in industry standard-setting
AI Biomaterial Composite Design Platform
Multi-physics simulation reduces experimental workload by over 50%
Key Milestones
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2026
Tendon stem cell IIT clinical trial was approved at the Second Affiliated Hospital of Zhejiang University.
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2026 Q2
PLLA microspheres have completed enrollment of 240+ patients (Class III medical device).
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2026
Longevity Clinic to be established in 2026.
